Two Sigma Ventures

The Opportunity

The ability to extract biologically and clinically meaningful signals from high content imaging data lies at the heart of insitro's efforts to accelerate drug development. As a Computational Microscopy Engineer IV, you will work with our world-class therapeutic discovery teams to prototype, develop, and scale microscopy methods and image analysis pipelines to better sense cellular state in the presence of treatments or genetic perturbations. You will report to the Senior Manager of the Computational Microscopy group, within the Imaging Machine Learning team. This is a hybrid position with the expectation of working 3 days per week onsite in our South San Francisco office.

Responsibilities

• Embed As a Microscopy Expert: Partner with therapeutic discovery teams to use insitro's imaging platform for industrial-scale drug target validation.
• Prototype Image Analysis Pipelines: Develop and implement computational imaging and computer vision algorithms from literature to detect phenotypes from pixel data
• Collaborate on Development: Work with software developers and machine learning engineers to design, test, and deploy scalable image processing pipelines for drug target validation
• Expert Resource: Join a team of experts for microscopy users within the company, creating training materials and hosting office hours to assist insitro scientists and engineers

About You

• Educational Background: Ph.D. in Biomedical Engineering, Computer Science, Physics, or a related field, or equivalent practical experience (e.g., M.S. with 3+ years of industry experience)
• Microscopy Knowledge: understanding of microscopy fundamentals, including components and modalities
• Software Skills: Proficient in developing software pipelines for image processing in Python
• Collaborative Communication: Comfortable collaborating with a diverse team, especially those in the biological sciences
• Mission-Driven: Enthusiasm for developing better therapeutic options for patients in need

Compensation & Benefits at insitro

Our target starting salary for successful US-based applicants for this role is $185,000 - $200,000. To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.

This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

In addition, insitro also provides our employees:

• 401(k) plan with employer matching for contributions
• Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees on our base plans), as well as mental health and well-being support
• Open, flexible vacation policy
• Paid parental leave
• Quarterly budget for books and online courses for self-development
• Support to attend professional conferences that are meaningful to your career growth and role's responsibilities
• New hire stipend for home office setup
• Monthly cell phone & internet stipend
• Access to free onsite baristas and cafe with daily lunch and breakfast
• Access to free onsite fitness center
• Commuter benefits

insitro is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We aim to bring together diverse teams–grounded in diverse expertise and life experiences–and work even harder to ensure those teams excel in inclusive, growth-oriented environments supported by equitable company and team practices. You can expect equitable treatment, respect, and fairness throughout the interview process.

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