Two Sigma Ventures

The Opportunity

We are looking for an Accounts Payable Manager with experience supervising colleagues, providing guidance, and ensuring the smooth execution of daily operations. Reporting to the Associate Director of Accounting, you will oversee full-cycle accounts payable, maintain full compliance with company policies, and collaborate with teams of scientists, engineers, and operational staff. You will also optimize accounts payable processes within Oracle and lead automation improvements to refine workflows, supporting the scalability required for our rapid growth.

This role is based in South San Francisco, with a hybrid approach of at least 3 days per week in the office and the option for the other 1-2 days from home.

Responsibilities

• Oversee the full-cycle accounts payable, including timely and accurate processing of invoices, expense reports, payments, reconciliations and process documentation
• Drive process improvement by leading projects to implement automation and increase productivity and efficiency
• Manage the corporate credit card program, including new card requests, card account reconciliations, and card administration
• Manage corporate travel platform, including user account maintenance, policy adherence and exception approvals, and reporting
• Manage quarterly use tax filings and 1099 year end filings in compliance with all state tax and IRS regulations, respectively
• Manage monthly accounts payable close including preparation of journal entries and account reconciliations
• Assist with financial audit requests and other ad-hoc requests and tasks as assigned

About You

• Bachelor degree in Business, Finance, Accounting or related field
• 5+ years of relevant work experience preferably in biotech
• Accounting ERP system experience, preferably in Oracle Cloud or similar
• Intermediate Excel skills and ability to work in G-Suite
• Detail-focused, ensuring accuracy in organizing and analyzing data
• Customer service oriented, can resolve issues through effective verbal and written communication

Compensation & Benefits at insitro

Our target starting salary for successful US-based applicants for this role is $120,000 - $135,000. To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.

This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

In addition, insitro also provides our employees:

• 401(k) plan with employer matching for contributions
• Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees on our base plans), as well as mental health and well-being support
• Open, flexible vacation policy
• Paid parental leave
• Quarterly budget for books and online courses for self-development
• Support to attend professional conferences that are meaningful to your career growth and role's responsibilities
• New hire stipend for home office setup
• Monthly cell phone & internet stipend
• Access to free onsite baristas and cafe with daily lunch and breakfast
• Access to free onsite fitness center
• Commuter benefits

insitro is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.

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