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Associate Scientist II / III, Metabolic Disorders



South San Francisco, CA, USA
Posted on Tuesday, April 16, 2024

The Opportunity

The heart of Insitro's strategy is the development of novel, cutting edge methods in machine learning and high-throughput biology that address key bottlenecks in the drug development pipeline. Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing epidemic and in its advanced form leads to liver cirrhosis and mortality. The metabolic diseases team at insitro is seeking a highly motivated candidate with cellular and molecular biology experience to support target discovery, validation and drug discovery efforts in MASLD. In this role the ideal candidate will be able to design and execute experiments, as well as analyze, interpret, and effectively communicate results. The candidate will work closely with their manager and other metabolic diseases TA scientists to support exploratory and portfolio efforts. Your responsibilities will likely evolve as the project advances and offer significant learning opportunities.

This is a lab-based role in our South San Francisco office, onsite 5x/week.


  • Culture and maintenance of primary and immortalized cell lines.
  • Execute medium and high throughput cell-based assays to advance MASLD phenotyping and validation efforts.
  • Conduct molecular biology experiments such as but not limited to transfection, gene expression analysis, immunostaining, ELISA and western blotting.
  • Maintain accurate documentation of experiments in electronic lab notebook (ELN) and follow all laboratory training and safety requirements
  • Collaborate effectively with teammates to provide scientific input and meet project goals.

About You

  • Bachelor's/ Master’s degree in Biology, Molecular Biology, Pharmacology or a relevant scientific subject area
  • At Least 5 years (for Bachelor’s) and 2 years (for Master’s) of laboratory based experience in academia and/or industry
  • Required - experience with mammalian cell culture techniques
  • Required - experience with cell based analytical assays, such as ELISA/western blot, biochemical assays, qPCR, fluorescence microscopy, flow cytometry etc
  • Experience with troubleshooting and incorporating insights/protocols from literature
  • Familiarity with oligonucleotide screening assays
  • Excellent organization and planning skills, ability to work in a fast-paced environment independently or as part of a team
  • Knowledge of metabolism and pharmacology (nice to have)

Compensation & Benefits at insitro

Our target starting salary for successful US-based applicants for this role is $90,000-$120,000. To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.

This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

In addition, insitro also provides our employees:

  • 401(k) plan with employer matching for contributions
  • Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees on our base plans), as well as mental health and well-being support
  • Open, flexible vacation policy
  • Paid parental leave
  • Quarterly budget for books and online courses for self-development
  • Support to occasionally attend professional conferences that are meaningful to your career growth and development
  • New hire stipend for home office setup
  • Monthly cell phone & internet stipend
  • Access to free onsite baristas and cafe with daily lunch and breakfast
  • Access to free onsite fitness center
  • Commuter benefits

insitro is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.


About insitro
insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitro’s approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit www.insitro.com.