Two Sigma Ventures

The Opportunity

The heart of insitro's strategy is the combination of novel, cutting edge methods in machine learning, biology at scale and drug discovery capabilities that address key bottlenecks in the drug development pipeline. To accomplish that, we are putting together an incredible team of highly talented drug discovery scientists who want to make a difference by bringing meaningful and accessible medicines to patients with unmet needs. In this role, you will report to the Associate Director, MedChem and will help build the medicinal chemistry and drug discovery capabilities. This role can be based in South San Francisco or remote; local candidates will have the option of a hybrid approach with three days per week in the office.

Primary Responsibilities:

• Support medicinal chemistry efforts through target design, synthetic route proposal and management of external, CRO-driven synthetic chemistry (intermediate synthesis, route scouting/optimization, scale-ups) across multiple projects
• Work cross-functionally to guide drug discovery projects through different stage gates towards clinical development candidates
• Explore approaches to utilize machine learning in drug discovery

About You

• BS with 10+ years of experience, MS with 8+ years of experience or Ph.D. in synthetic organic chemistry or medicinal chemistry with 4+ years of industrial drug discovery experience
• Demonstrated track record of advancing projects through different stages of drug discovery
• High level of creativity and productivity towards solving synthetic problems
• Working knowledge of drug discovery principles and techniques beyond medicinal chemistry
• Experience managing scientific collaboration and CRO resources
• Previous experience driving creative chemistry efforts towards project milestones
• Leadership experience in cross-functional teams as synthetic chemistry leader
• Experience with innovation and influence on projects through peer-reviewed publication and/or patent applications
• Passionate about pushing the boundaries of drug discovery with emerging technologies

Compensation & Benefits at insitro

Our target starting salary for successful US-based applicants for this role is $150,000 - $200,000. To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.

This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

In addition, insitro also provides our employees:

• 401(k) plan with employer matching for contributions
• Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees on our base plans), as well as mental health and well-being support
• Open, flexible vacation policy
• Paid parental leave
• Quarterly budget for books and online courses for self-development
• Support to occasionally attend professional conferences that are meaningful to your career growth and development
• New hire stipend for home office setup
• Monthly cell phone & internet stipend
• Access to free onsite baristas and cafe with daily lunch and breakfast
• Access to free onsite fitness center
• Commuter benefits

insitro is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.

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