Two Sigma Ventures

The Opportunity

Insitro is a pioneering company in the field of drug discovery and development, leveraging the power of machine learning and high-throughput biology to tackle significant challenges in the drug development process. Our focus areas include genetic epilepsies, neurodevelopmental diseases, metabolic disorders and oncology, with the goal of providing therapeutic solutions for patients through our innovative platform.

We are currently on the lookout for an Associate Scientist III / Scientist I, who possesses expertise in histology and microscopy, to become a part of our Research Operations team. In this capacity, you will work in collaboration with scientific and project colleagues to design and implement histology and microscopy workflows, analyze data, and enhance assays for our drug discovery initiatives.

We welcome individuals who are highly driven, with a strong aspiration to make a difference in the lives of patients through drug discovery. As a company, we are data-centric and believe that our potential for significant impact is greatest when we are bold enough to adopt unconventional approaches in our quest to deliver therapies to patients.

Responsibilities

• Perform tissue sectioning and preparation for histological analysis

• Run and maintain histology and microscopy equipment

• Optimize and validate antibodies and staining protocols

• Prepare and analyze data generated from histological experiments

• Develop and optimize assays for target identification and validation

• Collaborate with multidisciplinary teams to support drug development projects

• Maintain accurate documentation of experiments and follow laboratory safety protocols

About You

• PhD with 1 year of experience or BS/MS with a minimum of 5 years of experience in Biochemistry, Cell Biology, Pharmacology, or a relevant scientific field, with experience in histology sample preparation, data acquisition and analysis

• History of validating antibodies for use in immunofluorescence (IF), immunohistochemistry (IHC), immunocytochemistry (ICC), western blot (WB) or flow cytometry (FC)

• Experience in developing and executing cellular assays using microscopy and advanced imaging techniques

• Familiarity with coordination and shared documentation tools (Gsuite, Slack, Smartsheets)

• Strong organizational and communication skills

• Ability to work effectively in cross-functional teams

Nice to Have

• Experience and knowledge of cancer phenotypes

• Proficiency in analysis scripts (Python, R) and collaborative platforms (Benchling or Jupyter notebooks)

• Experience with sample and library preparation for genomics workflows

• Experience with flow cytometry

• Fluorescence in situ hybridization (FISH) multiplexed primary probe design

Compensation & Benefits at insitro

Our target starting salary for successful US-based applicants for this role is $100,000 - $135,000. To determine starting pay, we consider multiple job-related factors including a candidate’s skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.

This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

In addition, insitro also provides our employees:

insitro is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.