Two Sigma Ventures

About Hexagon Bio

Hexagon Bio leverages a genomics-based platform and understanding of natural product evolution to develop next-generationantibody-drug conjugates (ADCs) with novel payloads for cancer. We use data science, genomics, machine learning, synthetic biology, and automation to discover potent, evolutionarily refined small molecules from microbial genomes, and apply medicinal chemistry to optimize these molecules into truly transformative medicines.

We are expanding our medicinal chemistry team and have an opening at the Scientist I/II/Senior Scientist level. As a medicinal chemist at Hexagon Bio, you will work closely with the natural products chemistry, analytical chemistry, and biology teams to support drug discovery projects. You will design and synthesize novel, optimized small molecules to enable the discovery and characterization of ADC development candidates suitable for human clinical testing. You will have substantial opportunities to grow your career through project-associated activities and cross-functional interaction with the many scientific disciplines at Hexagon Bio.

Responsibilities:

• Structure-based and hypothesis-driven design of new ADC payload and linker-payload drug compounds
• Multistep synthesis, purification, and characterization of new ADC payload and linker-payload drug compounds
• May manage of aspects of a drug discovery program
• May manage chemistry at a contract research organization

Requirements:

• Scientist I: Ph.D. in organic or medicinal chemistry, and 0+ years postdoctoral and/or industry experience
• Scientist II: Ph.D. in organic or medicinal chemistry, and 2+ years postdoctoral and/or industry experience
• Senior Scientist: Ph.D. in organic or medicinal chemistry, and 4+ years postdoctoral and/or industry experience
• Ability to perform complex multistep synthesis quickly, efficiently, and safely
• Ability to effectively summarize and communicate research findings
• Ability to work full-time onsite at Menlo Park, CA laboratories

What We Offer:

• A flexible and dynamic work environment where you pave your own path, Hexagon cultivates employees' unique strengths at all levels and provides mobility across departments.
• “All Hands Meetings” provide an opportunity to share company and team updates. These meetings are rooted in our value of transparency. They are designed to foster a culture of collaboration, curiosity, and open communication.
• Rapid career advancement for driven performers.
• Access to scientific conferences all over the country throughout the year.
• A range of amenities, courtesy of the Menlo Park Labs business park, including shuttle, gym, rock-climbing wall, pool, sports courts, cafe, bike lockers, and free EV charging stations.
• Opportunities to engage with the Hexagon community through team-building events like our happy hours and holiday parties.

Additional Information:

The salary range is dependent on the level of experience. The salary range for this position is $120,000 - $180,000. Our salary ranges are determined by role, level, and location. The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across California locations. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training.

Hexagon Bio is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, disability status, membership in an organization, or any other non-merit factors

Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.