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Principal Scientist, Antibody Engineering

Hexagon Bio

Hexagon Bio

Menlo Park, CA, USA
Posted on Wednesday, April 17, 2024

About Hexagon Bio:

Hexagon Bio leverages a genomics-based platform and understanding of natural product evolution to develop next-generation medicines for human disease, including Antibody Drug Conjugates (ADCs) with novel payloads. Our algorithms identify gene clusters that encode the machinery needed to produce specialized metabolites and our unique platform allows us to produce new chemical leads and novel payloads based on these findings. We use data science, genomics, synthetic biology, and automation to discover and develop potent, evolutionarily refined small molecules from fungal genomes, paving the way for groundbreaking advancements in ADC therapeutics.

Location: Menlo Park, CA

Job description:

As Principal Scientist, Antibody Engineering, you will be part of a highly collaborative, interdisciplinary team, and will be responsible for the development and characterization of ADCs, contributing to the advancement of ground breaking therapeutic interventions. The candidate should be highly knowledgeable in therapeutic antibody discovery and engineering to enable the advancement of innovative ADCs. By driving collaborative efforts between cell biologists, chemists, and protein engineers the candidate will develop first-in-class ADC therapies. Candidates should demonstrate leadership, scientific curiosity, efficient time management, excellent organizational and communication skills, and a passion for science.

The role is expected to be a mix of management and laboratory work.

Key Responsibilities:

  • Lead antibody engineering, production and analytical efforts to develop novel therapeutic ADCs.
  • Produce engineered antibodies through mammalian expression and purification.
  • Perform in vitro cell-handling experiments, such as cell transfection, and cell transduction.
  • Perform antibody characterization using biological (multicolor flow cytometry, ADCC/CDC assays, ELISA, and imaging) and analytical methods (Octet/SPR, HPLC, SEC, IEX, mass spectrometry, endotoxin detection).
  • Work closely with biologists, protein engineers and chemists to advance antibody drug conjugates.
  • Analyze and interpret data, and effectively communicate findings to multi-disciplinary teams.


  • PhD in Biochemistry, Bioengineering, Biophysics, Structural Biology, or related disciplines with at least 5-8 years of experience in the biotech and/or pharma industry.
  • Extensive hands-on experience with therapeutic antibody discovery and engineering.
  • Extensive hands-on laboratory experience in all aspects of antibody expression, purification, and characterization (e.g. HPLC, IEX, LCMS).
  • Experience with biological assays (multicolor flow cytometry, microscopy, ELISA) and analytical approaches (e.g. Octet/SPR, HIC) for antibody and ADC characterization.
  • Experience working with Contract Development Manufacturing Organizations (CDMOs) is a plus.
  • Ability to tackle complex scientific problems in a cross-functional environment.
  • Effective communication and ability to coordinate tasks across multiple projects as part of a multidisciplinary research team.
  • Proven ability to coach and manage a team.
  • Initiative and boldness to dive into a fast-paced new startup.

What We Offer:

  • A flexible and dynamic work environment where you pave your own path, Hexagon cultivates employees' unique strengths at all levels and provides mobility across departments.
  • “All Hands Meetings” provide an opportunity to share company and team updates. These meetings are rooted in our value of transparency. They are designed to foster a culture of collaboration, curiosity, and open communication.
  • Competitive compensation and a robust benefits package: a comprehensive suite of medical, dental, and vision insurance plans through TriNet, which offers additional voluntary benefits (pet insurance, accident insurance, home & auto insurance, and more).
  • Equity and a 401(k) plan.
  • Rapid career advancement for driven performers.
  • Access to scientific conferences all over the country throughout the year.
  • A range of amenities, courtesy of the Menlo Park Labs business park, including shuttle, gym, rock-climbing wall, pool, sports courts, cafe, bike lockers, and free EV charging stations.
  • Opportunities to engage with the Hexagon community through team-building events like our monthly Hexagon Happy Hour and holiday parties.

Additional Information:

The salary range is dependent on the level of Scientist that is hired (Senior Scientist or Principal Scientist). The salary range for this full-time position is $150,000 - $190,000 + bonus + equity + benefits. Our salary ranges are determined by role, level, and location. The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across California locations. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training.

Hexagon Bio is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, disability status, membership in an organization, or any other non-merit factors

Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.