We believe the world is changing faster than ever

Join a Two Sigma Ventures portfolio company to help shape the future of technology.
Leverage our network to build your career.
Tell us about your professional DNA to get discovered by any company in our network with opportunities relevant to your career goals.

Director, Head of Medicinal Chemistry

Hexagon Bio

Hexagon Bio

Menlo Park, CA, USA
Posted on Saturday, February 11, 2023

About Hexagon Bio:

Hexagon Bio leverages a genomics-based platform and understanding of natural product evolution to develop next-generation medicines for human disease. Hexagon Bio's algorithms identify gene clusters that encode the machinery needed to produce specialized metabolites that can be harnessed against human disease targets. Our unique platform allows us to produce new chemical leads based on these findings. We use data science, genomics, synthetic biology, and automation to discover potent, evolutionarily refined small molecules and their cognate targets from fungal genomes, and apply medicinal chemistry when needed to optimize these molecules into truly transformative medicines.

Location: Menlo Park, California

Job Description:

We are expanding our medicinal chemistry team and have an opening for Director, Head of Medicinal Chemistry. As Director, Head of Medicinal Chemistry at Hexagon Bio, you will work closely with the leadership team to shape our medicinal chemistry strategy and build an industry-leading medicinal chemistry team. You will leverage your extensive drug discovery expertise to guide project teams from project initiation to clinical candidate identification and investigational new drug (IND) filing. You will have substantial opportunities to grow your career through interaction with the senior leadership team and cross-functional interaction with the many scientific disciplines at Hexagon Bio.


  • Build an industry-leading medicinal chemistry team
  • Shape medicinal chemistry strategy
  • Collaborate cross-functionally to advance Hexagon Bio’s pipeline
  • Oversee management of chemistry and drug discovery CROs
  • Inspire, mentor, and teach the next generation of medicinal chemists
  • Design and synthesis of new drug candidates
  • Facilitate metabolite identification, isolation, and characterization

Key Qualifications:

  • Ph.D. degree in organic or medicinal chemistry and 10+ years of experience in an industrial medicinal chemistry setting
  • Ability to build teams and inspire and mentor others
  • Track record of success advancing projects
  • Ability to work at Menlo Park, CA laboratories

What We Offer:

  • A flexible and dynamic work environment where you pave your own path, Hexagon cultivates employees' unique strengths at all levels and provides mobility across departments.
  • Weekly “All Hands Meetings” provide an opportunity to share company and team updates. These meetings are rooted in our value of transparency. They are designed to foster a culture of collaboration, curiosity, and open communication.
  • Competitive compensation and a robust benefits package: a comprehensive suite of medical, dental, and vision insurance plans through TriNet, which offers additional voluntary benefits (pet insurance, accident insurance, home & auto insurance, and more).
  • Equity and a 401(k) plan.
  • Rapid career advancement for driven performers.
  • Access to scientific conferences all over the country throughout the year.
  • A range of amenities, courtesy of the Menlo Park Labs business park, including shuttle, gym, rock-climbing wall, pool, sports courts, cafe, bike lockers, and free EV charging stations.
  • Opportunities to engage with the Hexagon community through team-building events like our monthly Hexagon Happy Hour and holiday parties.

Additional Information

The salary range for this full-time position is $180,000 to $250,000 + bonus + equity + benefits. Our salary ranges are determined by role, level, and location. The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across California locations. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training.

Hexagon Bio is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, disability status, membership in an organization, or any other non-merit factors.